Association of Kiss1 and GPR54 Gene Polymorphisms with Polycystic Ovary Syndrome among Sri Lankan Women

P-191: Association of STK11 Gene Polymorphisms with Methformin Treatment in Patients with Polycystic Ovary Syndrome

Background: Metformin is an insulin sensitizing drug, which is co-administered with Clominophene citrate or gonadotropins in most cases of polycystic ovary syndrome (PCOS), to improve ovulation. STK11 gene is necessary for action of metformin. Therefore the study of STK11 polymorphisms is important as pharmacogenetics aspects of metformin. The aim of our study was to investigate polymorphism of...

Association of vitamin D receptor gene polymorphisms with polycystic ovary syndrome among Indian women

BACKGROUND & OBJECTIVES The Vitamin-D receptor (VDR) regulates vitamin D levels and calcium metabolism in the body and these are known to be associated with endocrine dysfunctions, insulin resistance and type-2 diabetes in polycystic ovarian syndrome (PCOS). Studies on VDR polymorphisms among PCOS women are sparse. We undertook this study to investigate the association pattern of VDR polymorphi...

Sexual Functioning among Married Iranian Women with Polycystic Ovary Syndrome

Association Between the -1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome

Background: Tumor Necrosis Factor Alpha (TNF-α) gene, as an inflammatory factor, plays an important role in reproductive physiology, especially in women with Polycystic Ovary Syndrome (PCOS). Objective: This study aims to investigate the relationship between the -1031 T/C polymorphism of TNF-α gene and biochemical factors in women with PCOS. Methods: In this case-control study, participants w...

Statistical Genomic Approach Identifies Association between FSHR Polymorphisms and Polycystic Ovary Morphology in Women with Polycystic Ovary Syndrome

BACKGROUND Single-nucleotide polymorphisms (SNPs) in the follicle stimulating hormone receptor (FSHR) gene are associated with PCOS. However, their relationship to the polycystic ovary (PCO) morphology remains unknown. This study aimed to investigate whether PCOS related SNPs in the FSHR gene are associated with PCO in women with PCOS. METHODS Patients were grouped into PCO (n = 384) and non-...